T cell immunoglobulin and mucin-3 (TIM-3; HAVcr-2) is an immune checkpoint receptor involved in the suppression of both innate and adaptive immune cells. It is expressed on a wide variety of immune cells, including cytotoxic T cells, regulatory T cells (Tregs), natural killer (NK) cells and antigen-presenting cells (APCs) such as dendritic cells (DCs). TIM-3 suppresses effector cells through the interaction with a broad array of ligands: carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), galectin-9, phosphatidylserine (PS) and high mobility group box 1 (HMGB1). Blockade of TIM-3 can rescue NK-cell activity, promotes tumour antigen processing and reinvigorates exhausted T cells, restoring their proliferation and function.
LIT: Tim-3 and its role in regulating anti-tumor immunity: M. Das, et al.; Immunol. Rev. 276, 97 (2017) • TIM-3, a promising target for cancer immunotherapy: Y. He, et al.; Onco Targets Ther. 11, 7005 (2018)
Biologically Active TIM-3 and Galectin-9 Proteins
See all TIM-3 Proteins here.
See all HMGB1 Proteins here.
VALIDATED Antibodies for TIM-3 and Galectin-9 Research
See all VALIDATED Antibodies for TIM-3 and Galectin-9 Research here.
Originally posted on adipogen.com/tim-3-galectin-9-pathway/
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