For All Viral Vectors:
ViroMag
ViroMag Transduction Reagent is a magnetic nanoparticle formulation dedicated to increasing virus infection and transduction capacities; it is suitable for all viruses. Based on the Magnetofection™ technology, this reagent allows concentrating the complete applied dose of viral particles onto cells within minutes, inducing a significant improvement of virus transduction with extremely low vector doses. Due to its specific properties, ViroMag is ideal for infecting non-permissive cells. This reagent demonstrates an exceptionally high efficiency in promoting, controlling and assisting viral transductions so that no molecular biology processes or biochemical modifications are required.
- Increases transduction efficiency.
- Accelerates the transduction process.
- Efficient for hard-to-infect and non-permissive cells.
- Concentrates the viral dose onto the cells.
- Suitable for all types of viruses.
- Synchronise cell adsorption/infection without modifications of the viruses.
Viro-MICST™
Viro-MICST™ Transduction Reagent allows genetically modifying cells directly on magnetic cell purification columns. Based on the i-MICST™ Technology (Integrated Magnetic Immuno-Cell Sorting and Transfection/Transduction), this technology combines cell isolation and genetic modification in one simple and reliable integrated system. For efficient and selective gene delivery to target cells, Viro-MICST™ can be used in combination with any viral vector and allows you to reduce cell manipulation steps and save time and material.
- Highly efficient.
- Rapid, simple and ready to use.
- Suitable for all cells.
For Lenti & Retro Virus:
ViroMag RL
ViroMag R/L Transduction Reagent is a magnetic nanoparticle formulation optimised for Retroviruses and Lentiviruses. Based on the Magnetofection™ technology, this reagent allows concentrating the complete applied dose of Retro/Lentiviral particles onto cells within minutes, inducing a significant improvement of virus infectivity with extremely low vector doses. Due to its specific properties, ViroMag R/L is ideal for infecting non-permissive cells. This reagent demonstrates an exceptionally high efficiency in promoting, controlling and assisting viral transductions so that no molecular biology processes or biochemical modifications are required.
- Increase transduction efficiency.
- Accelerate the transduction process.
- Efficient for hard-to-infect and non-permissive cells.
- Concentrate the viral dose onto the cells.
- Suitable for all types of Retro/Lentivirus.
- Synchronise cell adsorption/infection without modifications of the viruses.
ViroMag RL can also be used for Genome Edition using the CRISPR-Cas9 system. It is designed for the transfection of a viral particle solution composed of either one viral vector or vectors encoding cas9 and sgRNA.
ViroMag Stem
ViroMag Stem, a Magnetofection-based Lentiviral Transduction Enhancer, enables improved viral-driven genetic modification in a wide range of stem cells in different applications, such as ex vivo gene therapy and cell therapy.
ViroMag Stem, as a stabilised magnetic nanoparticles formulation, offers a simple and reproducible method for increasing lentiviral infection and transduction of difficult cell types such as CD34+ hematopoietic stem cells, both cell lines and primary cells, in cell culture plate using the MagnetofectionTM technology.
This method combines maximum cell viability and high transduction efficiency, while cell phenotype and differentiation potential are not affected.
- Increase lentiviral transduction efficiency.
- Concentrate viral dose, promote and accelerate the transduction process.
- Efficient for hard-to-infect and non-permissive cells.
- Synchronise cell adsorption/infection.
Viro-MICST™ Stem
Viro-MICST™ Stem Transduction Enhancer is a new specific magnetic nanoparticle formulation issued from OZ Biosciences’ Magnetofection™ technology.
Its properties were specifically designed for Stem Cell lentiviral transduction in order to achieve a high infection rate directly on magnetic cell sorting devices (column or magnet).
As a stabilised magnetic nanoparticles formulation, Viro-MICST™ Stem offers a simple and reproducible method for increasing lentiviral infection and transduction of difficult cell types such as CD34+ hematopoietic stem cells, both cell lines and primary cells, during cell sorting.
Due to the total biodegradability of the magnetic nanoparticles, Viro-MICST™ Stem is non-toxic and ideal for CD34+ Hematopoietic Stem Cell transduction.
This technology combines cell isolation and genetic modification in one simple, efficient, and reliable integrated system. Viro-MICST™ Stem Transduction Reagent allows genetically modifying cells directly on magnetic cell purification columns. Based on the i-MICST™ Technology (Integrated Magnetic Immuno-Cell Sorting and Transfection/Transduction), this technology combines cell isolation and genetic modification in one simple and reliable integrated system.
- Increased Lentiviral Infection.
- Reduce cell manipulation steps and save time and material.
- Designed for stem cells.
LentiBlast Premium
LentiBlast Premium is a novel patented chemical composition that dramatically increases lentiviral infection and transduction efficiency in any type of cells, adherent or in suspension, primary or cell lines. The properties of this reagent allow simultaneously neutralising electrostatic repulsions between membrane and viral particles and enhancing viral fusion with the cell membrane. Due to a favourable “membrane permeable effect” limiting the transmembrane potential changes, LentiBlast Premium is non-toxic and compatible with cell viability.
LentiBlast Premium Transduction Enhancer overcomes obstacles that prevent successful transduction (cell density, passage number, lentivirus purity, MOI, …) and allows you to complete efficient transduction efficiencies without Polybrene.
LentiBlast Premium Transduction Enhancer benefits:
- Increase lentivirus infection efficiency for hard-to-transduce cells: The right solution for Stem cells, Primary T cells.
- Save effort & money: Achieve the same transduction results with a lower viral titer.
- Maximise Cell Viability: Non-toxic.
For Adenovirus:
AdenoMag
AdenoMag Transfection Reagent is a magnetic nanoparticle formulation specifically dedicated to enhancing Adenovirus and Adeno Associated Virus (AAV) infection and transduction capacities. Based on the Magnetofection™ technology, it allows concentrating the complete applied dose of viral particles onto cells within minutes, inducing a significant improvement of virus infectivity with extremely low vector doses. Due to its specific properties, AdenoMag is applicable to all adenoviral and AAV vectors and is ideal for infecting non-permissive cells. This reagent demonstrates an exceptionally high efficiency for promoting, controlling and assisting Adenoviral and AAV transductions in a way that no molecular biology processes or biochemical modifications are required.
- Increase transduction efficiency.
- Accelerate the transduction process.
- Efficient for hard-to-infect and non-permissive cells.
- Concentrate the viral dose onto the cells.
- Synchronise cell adsorption/infection without modifications of the viruses.
For Adeno-associated Virus:
AAVBlast
AAVBlast is a chemical AAV transduction enhancer, very effective in promoting viral-mediated genetic modification. AAVBlast improves transduction in a wide range of cell types from classic cell lines to primary cells or mesenchymal stem cells. Its patented formulation and unique thermoresponsive gelling properties, ensure the protection of viral particles and allow an increase in transduction efficiency. Non-toxic, the new AAVBlast AAV transduction enhancer is also compatible with in vivo experiments.
- Effective in a wide range of cell types: cell lines, primary cells, mesenchymal Stem Cells.
- Compatible with various serotypes.
- Thermoresponsive gelling properties: protection of viral particles.
- Non-toxic.
- Compatible with in-vivo experiments.
AAVBlast Transduction Enhancer benefits:
- Increase AAV infection efficiency for hard-to-transduce cells: The right solution for Stem cells, Primary T cells.
- Save effort & money: Achieve the same transduction results with a lower viral titer.
- Maximize Cell Viability: Non-toxic.
Information provided by OZ Biosciences.
Caltag Medsystems is the distributor of OZ Biosciences products in the UK and Ireland. If you have any questions about these products, please contact us.