JaICA

Hexanoyl-Lys [HEL] ELISA Kit

Product Code:
 
JAI-KHL-700E
Product Group:
 
ELISA Kits
Supplier:
 
JaICA
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
BLUE ICE
Storage:
 
+4°C
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JAI-KHL-700E-1Kit1 Kit£871.00
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Further Information

Assay Type:
Competitive
Detection Type:
Colorimetric
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Do not freeze.
Long Description:
Kit. Specific to N-epsilon-Hexanoyl-Lysine adduct. Range: 2 - 700 nmol/L. Oxidative damage to lipids (lipid peroxidation) has been found to play an important role in various disease and aging processes. During early stages of lipid peroxidation, lipid hydroperoxides (LOOH) are formed. These can react additionally to form later stage end products such as malondialdehyde (MDA) and hydroxynonenal (HNE). LOOH is measured to quantify early stage or acute lipid peroxidation while MDA is commonly measured to quantify late stage or chronic lipid peroxidation. More recently, it has been reported that 13-hydroperoxyoctadecanoic acid (13-HPODE), a precursor to 13-hydroxyoctadecanoic acid (13-HODE) can react with proteins to form measurable adducts by covalently binding to specific amino acid residues. The Hexanoyl-Lysine (HEL) adduct is formed upon oxidative modification of omega-6 fatty acids such as linoleic acid, the predominant polyunsaturated fatty acid (PUFA) in the human diet, and arachidonic acid. HEL may be another useful biomarker for detecting and quantifying the earlier stages of lipid peroxidation. This ELISA Kits works also for DNA extracted from cultured cells or tissues.
Other data:
This ELISA Kits works also for DNA extracted from cultured cells or tissues.
Package Type:
Box
Product Description:
Oxidative damage to lipids (lipid peroxidation) has been found to play an important role in various disease and aging processes. During early stages of lipid peroxidation, lipid hydroperoxides (LOOH) are formed. These can react additionally to form later stage end products such as malondialdehyde (MDA) and hydroxynonenal (HNE). LOOH is measured to quantify early stage or acute lipid peroxidation while MDA is commonly measured to quantify late stage or chronic lipid peroxidation. More recently, it has been reported that 13-hydroperoxyoctadecanoic acid (13-HPODE), a precursor to 13-hydroxyoctadecanoic acid (13-HODE) can react with proteins to form measurable adducts by covalently binding to specific amino acid residues. The Hexanoyl-Lysine (HEL) adduct is formed upon oxidative modification of omega-6 fatty acids such as linoleic acid, the predominant polyunsaturated fatty acid (PUFA) in the human diet, and arachidonic acid. HEL may be another useful biomarker for detecting and quantifying the earlier stages of lipid peroxidation.
Range:
2 - 700 nmol/L
Sample Type:
Serum, Urine
Specificity:
Specific to N-epsilon-Hexanoyl-Lysine adduct.
Transportation:
Non-hazardous
UNSPSC Category:
ELISA Kits
UNSPSC Number:
41116126
Use & Stability:
12 months after the day of manufacturing. See expiry date on ELISA Kit box.

References

Preparation of a monoclonal antibody to N(epsilon)-(Hexanonyl)lysine: application to the evaluation of protective effects of flavonoid supplementation against exercise-induced oxidative stress in rat skeletal muscle: Y. Kato, et al.; BBRC 274, 389 (2000) [Development and characterization of anti HEL monoclonal antibody] | Possible involvement of oxidative stress in salivary gland of patients with Sjogren's syndrome: K. Ryo, et al.; Pathobiology 73, 252 (2006) [Detection of HEL in saliva samples from patients with Sjogren's syndrome] | Effect of prophylactically administered edaravone during antegrade cerebral perfusion in a canine model of old cerebral infarction: T. Suzuki, et al.; J. Thorac. Cardiovasc. Surg. 133, 710 (2007) [Detection in canine serum samples] | Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate: H. Tamura, et al.; J. Pineal. Res. 44, 280 (2008) [Intrafollicular concentration of HEL was significantly reduced by antioxidant treatment] | Etanercept reduces the oxidative stress marker levels in patients with rheumatoid arthritis: Y. Kageyama, et al.; Rheumatol. Int. 28, 245 (2008) [Reduced urinary HEL levels after initial treatment with etanercept] | Tear cytokine and ocular surface alterations following brief passive cigarette smoke exposure: V.T. Rummenie, et al.; Cytokine 43, 200 (2008) [Increased HEL concentration in tear by brief passive exposure to cigarette smoke]