ProSci

CD49b Antibody [DX5] (FITC)

Product Code:
 
PSI-98-959
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rat
Antibody Isotype:
 
IgM
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
[DX5]
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
blue ice
Storage:
 
Store vial at 2-8˚C
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PSI-98-959-0.5mg0.5mg£597.00
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Further Information

Additional Names:
alpha2 integrin, VLA-2alpha, very late antigen-2, pan NK
Application Note:
CD49b Antibody [DX5] for use in flow cytometry and immunohistochemistry assays.
Background:
The monoclonal antibody DX5 reacts with CD49b, also known as very late antigen-2 (VLA-2) and alpha2 integrin. The antibody stains the majority of NK cells and a small subpopulation of T cells in all mouse strains tested (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, CBA/J, DBA/1, DBA/2, SJL, SWR). Three-color flow cytometry analysis has revealed that most cells that express NK-1.1 (NKR-P1C) also express CD49b. However, small subsets of DX5+NK-1.1- and DX5-NK-1.1+ cells can be found, especially among the CD3+ population of T lymphocytes. NK cells cultured in the presence of IL-2 progressively lose reactivity with DX5 as a consequence of cellular proliferation. Therefore, DX5 can be used to define functionally distinct subsets of murine NK cells. The monoclonal antibody DX5 has not been demonstrated to have activating or blocking activity.
Buffer:
Supplied in PBS/NaN3
Concentration:
0.5 mg/mL
Conjugate:
FITC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NK cells isolated from C57BL/6 mice
NCBI Gene ID #:
16398
NCBI Official Name:
integrin alpha 2
NCBI Official Symbol:
Itga2
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
Q62469
Research Area:
Immunology
SPECIFICITY:
CD49b
Swissprot #:
Q62469
User NOte:
Optimal dilutions for each application to be determined by the researcher.