5-Aminolevulinic acid hydrochloride
Product Code:
CDX-A0364
CDX-A0364
Regulatory Status:
RUO
RUO
Shipping:
Ambient
Ambient
Storage:
+4°C
+4°C
No additional charges, what you see is what you pay! *
Code | Size | Price |
---|
CDX-A0364-M500 | 500 mg | £72.00 |
Quantity:
CDX-A0364-G001 | 1 g | £108.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
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Further Information
Alternate Names/Synonyms:
delta-Aminolevulinic acid hydrochloride; 5-Amino-4-oxopentanoic acid hydrochloride; 5-Aminolaevulinic acid hydrochloride; 5-ALA
Appearance:
White to off-white powder.
CAS:
02/09/5451
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Keep under inert gas.Very hygroscopic.
InChi:
InChI=1S/C5H9NO3.ClH/c6-3-4(7)1-2-5(8)9;/h1-3,6H2,(H,8,9);1H
InChiKey:
ZLHFONARZHCSET-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 5451-09-2. Formula: C5H9NO3 . HCl. MW: 131.13 . 36.46. 5-Aminolevulinic acid (5-ALA) is a non-proteinogenic five carbon amino acid, which is the precursor for the biosynthesis of tetrapyrrole compounds, such as heme, chlorophyll and vitamin B12 and has broad applications in the medical and agricultural fields. The conversion of 5-ALA to protoporphyrins within tissues produces a photosensitive target that produces reactive oxygen species upon exposure to light. In this way, it is used in photodynamic therapy for a range of dermatological conditions, cancers, and other diseases. Oral administration of 5-ALA leads to the preferential accumulation of the fluorescent molecule protoporphyrin IX within certain types of cancer cells. This allows fluorescence-based identification of tumor tissue for accurate resection of diseased tissue. In addition to tumor therapy, 5-ALA has been implicated in the treatment of inflammatory disease, autoimmune disease and transplantation due to the anti-inflammation and immunoregulation properties that are elicited with the expression of heme oxygenase (HO)-1. ALA-based photodynamic therapy (PDT) has also a role in the treatment of microbial infections.
MDL:
MFCD00012869
Molecular Formula:
C5H9NO3 . HCl
Molecular Weight:
131.13 . 36.46
Package Type:
Vial
Product Description:
5-Aminolevulinic acid (5-ALA) is a non-proteinogenic five carbon amino acid, which is the precursor for the biosynthesis of tetrapyrrole compounds, such as heme, chlorophyll and vitamin B12 and has broad applications in the medical and agricultural fields. The conversion of 5-ALA to protoporphyrins within tissues produces a photosensitive target that produces reactive oxygen species upon exposure to light. In this way, it is used in photodynamic therapy for a range of dermatological conditions, cancers, and other diseases. Oral administration of 5-ALA leads to the preferential accumulation of the fluorescent molecule protoporphyrin IX within certain types of cancer cells. This allows fluorescence-based identification of tumor tissue for accurate resection of diseased tissue. In addition to tumor therapy, 5-ALA has been implicated in the treatment of inflammatory disease, autoimmune disease and transplantation due to the anti-inflammation and immunoregulation properties that are elicited with the expression of heme oxygenase (HO)-1. ALA-based photodynamic therapy (PDT) has also a role in the treatment of microbial infections.
Purity:
>98% (HPLC)
SMILES:
[NH3+]CC(CCC(O)=O)=O.[Cl-]
Solubility Chemicals:
Soluble in DMSO (10mg/ml), methanol (10mg/ml) or water (10mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
Documents
References
(1) S.L. Marcus, et al.; J. Clin. Laser Med. Surg. 14, 59 (1996) | (2) Q. Peng, et al.; Photochem. Photobiol. 65, 235 (1997) | (3) S.A. Friesen, et al.; Int. J. Oncol. 21, 577 (2002) | (4) M.C. Issa & M. Manela-Azulay; An. Bras. Dermatol. 85, 501 (2010) | (5) F. Harris & L. Pierpoint; Med. Res. Rev. 32, 1292 (2012) | (6) M. Fujino, et al.; Int. Immunopharmacol. 37, 71 (2016) | (7) S.H. Halani & D.C. Adamson; Onco. Targets Ther. 9, 5629 (2016) | (8) M.O. Chohan & M.S. Berger; J. Neurooncol. (Epub ahead of print) (2018)