Further Information
CTNNB1, CTNNB, MRD19, armadillo
WB: 1:500 - 1:2000
IF: 1:50 - 1:100
IP: 1:20 - 1:50
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant protein of human beta Catenin
1499
catenin (cadherin-associated protein), beta 1, 88kDa
CTNNB1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 100kDa
Affinity purification
Apoptosis, Cancer, Cell Cycle, Immunology, Neuroscience, Signal Transduction, Stem Cell, Transcription
P35222
Optimal dilutions for each application to be determined by the researcher.