Further Information
EL2, HPP, HS3, SPH3, SPTA, spectrin alpha chain, erythrocytic 1, alpha-I spectrin, elliptocytosis 2, erythroid alpha-spectrin, spectrin alpha chain, erythrocyte
WB: 1:500 - 1:2000
IF: 1:50 - 1:200
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 940-1160 of human SPTA1 (NP_003117.2).
6708
spectrin alpha, erythrocytic 1
SPTA1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 300kDa
Affinity purification
Cell Cycle, Signal Transduction
P02549
Optimal dilutions for each application to be determined by the researcher.