COL1A1 Antibody

Alpha-1 type I collagenOI4

WB: 1:500 - 1:1000

IHC: 1:50 - 1:200

IF: 1:50 - 1:200

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human COL1A1 (NP_000079.2).

1277

collagen, type I, alpha 1

COL1A1

Homo sapiens

Liquid

Observed: 139kDa

Affinity purification

Other

P02452

Optimal dilutions for each application to be determined by the researcher.