ProSci

TIMP2 Antibody

Product Code:
 
PSI-16-606
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Shipping:
 
Blue Ice or RT
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western blot analysis of extracts of various cell lines, using TIMP2 antibody (16-606) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.<br/>Detection: ECL Basic Kit.<br/>Exposure time: 90s.
2 / 4
Immunohistochemistry of paraffin-embedded Rat ovary using TIMP2 antibody (16-606) at dilution of 1:100 (40x lens).
3 / 4
Immunohistochemistry of paraffin-embedded Human breast cancer using TIMP2 antibody (16-606) at dilution of 1:150 (40x lens).
4 / 4
Immunohistochemistry of paraffin-embedded Mouse pancreatic islet using TIMP2 antibody (16-606) at dilution of 1:150 (40x lens).
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Western blot analysis of extracts of various cell lines, using TIMP2 antibody (16-606) at 1:1000 dilution.<br/>Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.<br/>Lysates/proteins: 25ug per lane.<br/>Blocking buffer: 3% nonfat dry milk in TBST.<br/>Detection: ECL Basic Kit.<br/>Exposure time: 90s.
Immunohistochemistry of paraffin-embedded Rat ovary using TIMP2 antibody (16-606) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded Human breast cancer using TIMP2 antibody (16-606) at dilution of 1:150 (40x lens).
Immunohistochemistry of paraffin-embedded Mouse pancreatic islet using TIMP2 antibody (16-606) at dilution of 1:150 (40x lens).

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PSI-16-606-100uL100 uL£565.00
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Further Information

Additional Names:
TIMP2, Metalloproteinase inhibitor 2, TIMP-2, CSC-21K
Application Note:
WB: 1:500 - 1:2000

IHC: 1:50 - 1:200
Background:
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TIMP2 (NP_003246.1).
NCBI Gene ID #:
7077
NCBI Official Name:
TIMP metallopeptidase inhibitor 2
NCBI Official Symbol:
TIMP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 26kDa
Purification:
Affinity purification
Research Area:
Cancer, Cell Cycle, Signal Transduction
Swissprot #:
P16035
User NOte:
Optimal dilutions for each application to be determined by the researcher.