Further Information
CTRCT41, WFRS, WFS, WFSL, wolframin, Wolfram syndrome 1 (wolframin)
WB: 1:500 - 1:2000
This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human WFS1 (NP_001139325.1).
7466
wolframin ER transmembrane glycoprotein
WFS1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 110kDa
Affinity purification
Cancer, Cell Cycle, Growth Factors, Neuroscience, Signal Transduction
O76024
Optimal dilutions for each application to be determined by the researcher.