Further Information
CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human CYP1A1 (NP_000490.1).
1543
cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 63kDa
Affinity purification
Cancer, Signal Transduction
P04798
Optimal dilutions for each application to be determined by the researcher.