Further Information
Cxcr2, mIL-8RH, interleukin-8 receptor type B, interleukin 8 receptor, beta, IL-8Rh, IL-8rb, Il8rb, IL8RA, IL-8R B, IL-8 receptor alpha chain, high affinity interleukin-8 receptor B, GRO/MGSA receptor, Gpcr16, CXC-R2, CXCR-2, C-X-C chemokine receptor type 2, Cmkar2, chemokine (C-X-C) receptor 2, chemokine (C-X-C motif) receptor 2, CDw128, CD128, IL8RB
WB: 1:500 - 1:2000
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant protein of human CXCR2.
3579
chemokine (C-X-C motif) receptor 2
CXCR2
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 41kDa
Affinity purification
Apoptosis, Cell Cycle, Immunology, Signal Transduction
P25025
Optimal dilutions for each application to be determined by the researcher.