Further Information
MTH1, 7,8-dihydro-8-oxoguanine triphosphatase, 2-hydroxy-dATP diphosphatase, 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase, 8-oxo-7,8-dihydroguanosine triphosphatase, 8-oxo-dGTPase, mutT human homolog 1, nucleoside diphosphate-linked moiety X motif 1, nucleoside diphosphate-linked moiety X-type motif 1, nudix (nucleoside diphosphate linked moiety X)-type motif 1, nudix motif 1
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human NUDT1 (NP_945192.1).
4521
nudix hydrolase 1
NUDT1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 18kDa
Affinity purification
Other
P36639
Optimal dilutions for each application to be determined by the researcher.