Further Information
UGT1A4, HUG-BR2, UDPGT, UGT1D, UGT-1D, UGT1.4, UGT1-04, UDPGT 1-4
WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 29-150 of human UGT1A4 (NP_009051.1).
54657
UDP glucuronosyltransferase 1 family, polypeptide A4
UGT1A4
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 69kDa
Affinity purification
Cell Cycle, Signal Transduction
P22310
Optimal dilutions for each application to be determined by the researcher.