Further Information
PPARD, FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB
WB: 1:500 - 1:2000
IF: 1:50 - 1:200
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
batch dependent
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Recombinant fusion protein containing a sequence corresponding to amino acids 102-361 of human PPARD (NP_803184.1).
5467
peroxisome proliferator-activated receptor delta
PPARD
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
Observed: 56kDa
Affinity purification
Apoptosis, Cancer, Cell Cycle, Obesity, Signal Transduction, Transcription
Q03181
Optimal dilutions for each application to be determined by the researcher.