ERBB4 Antibody

ERBB4, ERBB 4, HER4, p180 erb4, p180erbB4

WB: 1:500 - 1:1000

IHC: 1:50 - 1:100

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

batch dependent

Unconjugated

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Recombinant fusion protein containing a sequence corresponding to amino acids 26-160 of human ERBB4 (NP_005226.1).

2066

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

ERBB4

Homo sapiens

Liquid

Observed: 180kDa

Affinity purification

Cancer, Cell Cycle, Growth Factors, Immunology, Signal Transduction

Q15303

Optimal dilutions for each application to be determined by the researcher.