ProSci

IL2 Recombinant Protein (e.coli Expressed)

Product Code:
 
PSI-97-076
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Shipping:
 
Blue Ice or room temp
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-97-076-0.1mg0.1mg£524.00
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Further Information

Additional Names:
IL2, TCGF, lymphokine, Interleukin 2
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.
Background References:
  • Gaffen, S.L. and K.D. Liu, 2004, Cytokine 28:109.
  • Kasakura S, Lowenstein L, 1965, Nature 208 (5012): 794?795.
  • Smith KA, Favata MF, Oroszlan S, 1983, J. Immunol. 131 (4): 1808.
  • Thornton AM, Shevach EM, 1998, J. Exp. Med.?188?(2): 287?96.
Biological Activity:
The bio-activity was determined by dose-dependent stimulation of the proliferation of mouse CTLL-2 cells. The ED50 for this effect is 0.284-0.355 ng/ml (Routinely tested).
Buffer:
Lyophilized from 0.22 um filtered solution in PBS, pH5.0. Normally trehalose is added as protectant before lyophilization
Fusion Tag:
Tag free
NCBI Gene ID #:
3558
NCBI Official Name:
interleukin 2
NCBI Official Symbol:
IL2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
15.4 kDa
Protein Accession #:
P60568
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P60568

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