ProSci

GFR alpha-like Recombinant Protein

Product Code:
 
PSI-11-410
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-410-0.1mg0.1mg£729.00
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Further Information

Additional Names:
GFR alpha like,GFR alpha-like,GFRAL,GRAL
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.7 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
GFR alpha-like is also known as GDNF family receptor alpha-like, GFRAL, C6orf144, UNQ9356, PRO34128. Growth differentiation factor-15 (GDF15) is a circulating protein that has been implicated in multiple biological processes, including energy homeostasis, body weight regulation, and cachexia driven by cancer and chronic disease. GDNF family receptor α-like (GFRAL) was recently identified as the neuronal brainstem receptor responsible for mediating the anorectic actions of GDF15. Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses . Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Background References:
  • Hsu JY, et al. 2017. Nature. 550(7675):255-259. (2) Mullican SE, et al. 2018. Trends Endocrinol Metab. 29(8):560-570. (3) Mullican SE, et al. 2017. Nat Med. 1150-1157.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
389400
NCBI Official Name:
GDNF family receptor alpha like
NCBI Official Symbol:
GFRAL
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
39.7 kDa
Protein Accession #:
NP_997293.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q6UXV0

Documents