ProSci

PTK7 / CCK4 Recombinant Protein

Product Code:
 
PSI-11-124
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Host Type:
 
Human
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
blue ice or RT
Storage:
 
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
 

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PSI-11-124-0.1mg0.1mg£729.00
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Further Information

Additional Names:
PTK7,CCK4,CCK-4,Tyrosine-protein kinase-like 7,Protein-tyrosine kinase 7,Protein-tyrosine kinase 7
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76.5 kDa. The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background:
PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Background References:
  • Won-Sik Shin, et al. Biochem Biophys Res Commun. 2008. 371(4):793-8.
  • Thomas Prebet, et al. Blood. 2010. 116(13):2315-23.
  • Vladislav S Golubkov, et al. J Biol Chem. 2010. 285(46):35740-9.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
5754
NCBI Official Name:
proteintyrosinekinase7(inactive)
NCBI Official Symbol:
PTK7
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
76.5 kDa
Protein Accession #:
NP_002812.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
#N/A
Source:
HEK293 cells
Swissprot #:
Q13308

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