DR1 Antibody (Down-regulator of transcription 1)

Western blot: 1:1000

Titration of the DR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

A portion of amino acids 83-112 from the human protein was used as the immunogen for this DR1 antibody.

This DR1 antibody is available for research use only.

Antigen affinity

Human, Mouse

Rat, Chicken

Q01658