NSJ Bioreagents

ALK Antibody / Anaplastic Lymphoma Kinase

Product Code:
 
NSJ-V8812
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG2b, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
ALK/1032
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Aliquot the Anaplastic Lymphoma Kinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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Western blot testing of a recombinant ALK partial protein using Anaplastic Lymphoma Kinase antibody (clone ALK/1032).
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Western blot testing of a recombinant ALK partial protein using Anaplastic Lymphoma Kinase antibody (clone ALK/1032).

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CodeSizePrice
NSJ-V8812-20UG20ug£264.00
Quantity:
NSJ-V8812-100UG100ug£534.00
Quantity:
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Further Information

Application Details :
Western blot: 1-2ug/ml
Application Note:
Optimal dilution of the Anaplastic Lymphoma Kinase antibody should be determined by the researcher.
Description:
The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.
Format :
Purified
Formulation :
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
A portion of amino acids 220-335 was used as the immunogen for the Anaplastic Lymphoma Kinase antibody.
Limitation:
This Anaplastic Lymphoma Kinase antibody is available for research use only.
Localization:
Cytoplasmic, Nuclear
PM_Meta_Key:
Product_Images
PM_Meta_Value:
https://www.nsjbio.com/get_image.php?catalog_no=V8812-100UG&type=image1~Western blot testing of a recombinant ALK partial protein using Anaplastic Lymphoma Kinase antibody (clone ALK/1032).|https://www.nsjbio.com/get_image.php?catalog_no=V8812-100UG&type=image2~SDS-PAGE analysis of purified, BSA-free Anaplastic Lymphoma Kinase antibody (ALK/1032) as confirmation of integrity and purity.
Purity:
Protein A/G affinity
Species Reactivity :
Human
Uniprot #:
Q9UM73