ScienCell's GeneQuery™ Human Bipolar, Personality, and Mood Disorders qPCR Array Kit (GQH-BPM) profiles 88 key genes associated with personality and mood disorders. Personality disorders are mental illnesses, often first appearing during the teenage years or early adulthood, which involve unhealthy patterns of thinking and behavior that disrupt social abilities. These are divided into three classifications: Cluster A disorders (Schizoid, Paranoid, Schizotypal), Cluster B disorders (Antisocial, Borderline, Histrionic, Narcissistic), and Cluster C disorders (Avoidant, Dependent, Obsessive-compulsive). Mood disorders distort a person's emotional state or mood in a way that interferes with their ability to function. Common mood disorders include Major Depressive Disorder, Bipolar Disorder, Seasonal Affective Disorder (SAD), and Dysthymia. Brief examples of how included genes may be grouped according to their functions are shown below:
- Major Depressive Disorder: - CCKAR, CREB1, CRHR1, CRHR2, FGF2, FGFR1, FKBP5, FMR1, GNB3, GRIN1, HTR1A, HTR3B, ID3, LHPP, MT1M, NEGR1, NR3C1, PRIMA1, PTGS2, RAC1, RNF123, SDK1, SIRT1, SLC6A15, SLC6A4, TOR1A, TPPP
- Mood Disorders: - ARNTL, CLOCK, DAOA, ESR1, GRM7, GSK3B, HTR2C, NPAS2, OPN4, PER2, SIGMAR1, ZBTB20
- Bipolar Disorder: - ANK3, CAMK2A, DAO, DBP, DGKH, DRD1, GC, GNAL, HTR3A, IMPA2, LMAN2L, MDGA1, MPPE1, MYO5B, NCAM1, NCAN, PER3, RORA, RORB, SHANK3, SLC6A3, SYNE1, TENM4, TRANK1, VIP, ZNF804A
- Cluster A Personality Disorders: - CACNA1C, COMT, DISC1, DRD2, DTNBP1, NRG1
- Cluster B Personality Disorders: - APBA2, APBA3, BDNF, CCKAR, COL25A1, COMT, CRHR2, FAAH, FKBP5, GRIN2B, HTR1B, HTR2A, KCNQ1, MAOA, MAOB, MCF2, NINJ2, NR3C1, OXTR, PRIMA1, SLC6A4
- Cluster C Personality Disorders: - DRD3, DRD4, TPH2
GeneQuery™ qPCR array kits are qPCR ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg^2+ , and no DMSO); (ii) the primer set recognizes all known transcript variants of target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.
ScienCell's GeneQuery™ Human Bipolar, Personality, and Mood Disorders qPCR Array Kit (GQH-BPM) profiles 88 key genes associated with personality and mood disorders. Personality disorders are mental illnesses, often first appearing during the teenage years or early adulthood, which involve unhealthy patterns of thinking and behavior that disrupt social abilities.
