TargetMol

Isosilybin

Product Code:
 
TAR-T3797
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3797-1mg1mg£95.00
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TAR-T3797-5mg5mg£125.00
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TAR-T3797-1mL1 mL * 10 mM (in DMSO)£128.00
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TAR-T3797-10mg10mg£155.00
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TAR-T3797-25mg25mg£254.00
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TAR-T3797-50mg50mg£412.00
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TAR-T3797-100mg100mg£575.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
Isosilybin and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patients.
CAS:
72581-71-6
Formula:
C25H22O10
Molecular Weight:
482.441
Pathway:
Metabolism
Purity:
0.98
SMILES:
COc1cc(ccc1O)C1Oc2ccc(cc2OC1CO)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O
Target:
P45

References

Pferschy-Wenzig EM, et al. Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. J Nat Prod. 2014 Apr 25;77(4):842-7. Mooiman KD, et al. Milk thistle's active components silybin and isosilybin: novel inhibitors of PXR-mediated CYP3A4 induction. Drug Metab Dispos. 2013 Aug;41(8):1494-504. Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27(28):31986-98. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.