TargetMol

Jaceosidin

Product Code:
 
TAR-T3824
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T3824-1mg1mg£112.00
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TAR-T3824-1mL1 mL * 10 mM (in DMSO)£143.00
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TAR-T3824-5mg5mg£171.00
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TAR-T3824-10mg10mg£229.00
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TAR-T3824-25mg25mg£389.00
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TAR-T3824-50mg50mg£547.00
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TAR-T3824-100mg100mg£751.00
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Further Information

Bioactivity:
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway, leading to inactivation of the Cdc2-cyclin B1 complex, followed by G2/M cell cycle arrest in endometrial cancer cells. Jaceosidin has immunosuppressive effect through inhibiting T cell proliferation and activation, which is closely associated with its potent down-regulation of the IFN-γ/STAT1/T-bet signaling pathway. The pharmacokinetics of Jaceosidin may be dramatically affected by polymorphic CYP1A2, UGT1A1, and UGT1A7 responsible for the metabolism of Jaceosidin or by the coadministration of relevant CYP1A2 or UGT inhibitors or inducers.
CAS:
18085-97-7
Formula:
C17H14O7
Molecular Weight:
330.292
Pathway:
Immunology/Inflammation; Metabolism; Neuroscience; Apoptosis
Purity:
0.9997
SMILES:
COc1cc(ccc1O)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1
Target:
Apoptosis; BCL; COX; UGT

References

Song WY, et al. In vitro metabolism of jaceosidin and characterization of cytochrome P450 and UDP-glucuronosyltransferase enzymes in human liver microsomes. Arch Pharm Res. 2010 Dec;33(12):1985-96.