TargetMol

Actein

Product Code:
 
TAR-T7190
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7190-1mg1mg£302.00
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TAR-T7190-5mg5mg£563.00
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TAR-T7190-1mL1 mL * 10 mM (in DMSO)£703.00
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TAR-T7190-10mg10mg£768.00
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TAR-T7190-25mg25mg£1,107.00
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TAR-T7190-50mg50mg£1,460.00
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  • Further Information
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Further Information

Bioactivity:
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways involved in lipid disorders and carcinogenesis may make it a new agent for preventing and treating these major disorders, it has been shown to inhibit the proliferation of human breast cancer cells, by altering the activity of the ER IP3 receptor and Na,K-ATPase, inducing calcium release and modulating the NF-kB and MEK pathways.
CAS:
18642-44-9
Formula:
C37H56O11
Molecular Weight:
676.83
Pathway:
Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; MAPK; Autophagy
Purity:
0.98
SMILES:
C[C@]12[C@]3([C@]4([C@]5(C4)[C@@](CC3)(C(C)(C)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@H](O)CO6)CC5)[H])C[C@@H](OC(C)=O)[C@]1(C)[C@@]7([C@](C2)(O[C@@]8(C[C@H]7C)[C@]9([C@](C)(O9)[C@@H](O)O8)[H])[H])[H])[H]
Target:
Apoptosis; Akt; JNK; Autophagy

References

Actein isolated from black cohosh promotes the function of osteoblastic MC3T3-E1 cells. J Med Food. 2014 Apr;17(4):414-23.