TargetMol

Guanfu base A

Product Code:
 
TAR-T8182
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T8182-1mg1mg£148.00
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Further Information

Bioactivity:
Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
CAS:
1394-48-5
Formula:
C24H31NO6
Molecular Weight:
429.513
Pathway:
JAK/STAT signaling; Metabolism; Angiogenesis; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
Purity:
0.9971
SMILES:
CC(=O)O[C@H]1C[C@]2(C)CN3[C@H]4C[C@]56CC(=C)[C@@H]7[C@@H](O)[C@H]5[C@](C1)([C@@H]24)[C@H]3[C@@]6(O)C7OC(C)=O
Target:
P45; Potassium Channel; HER

References

Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24.