TargetMol

6-Diazo-5-oxo-L-nor-Leucine

Product Code:
 
TAR-T8373
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T8373-1mg1mg£104.00
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TAR-T8373-1mL1 mL * 10 mM (in DMSO)£135.00
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TAR-T8373-5mg5mg£172.00
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Further Information

Bioactivity:
L-6-Diazo-5-oxonorleucine is an antagonist of glutaminases (Ki : 6 μM). It is an antineoplastic antibiotic produced by an unidentified species of Streptomyces from Peruvian soil.
CAS:
157-03-9
Formula:
C6H9N3O3
Molecular Weight:
171.156
Pathway:
Proteases/Proteasome; Microbiology/Virology
Purity:
0.98
SMILES:
N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
Target:
Influenza Virus; Glutaminase; Antibacterial; Antibiotic

References

Willis RC, et al. The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. J Cell Physiol. 1977 Dec;93(3):375-82. Turley E A . The Control of Adrenocortical Cytodifferentiation by Extracellular Matrix***[J]. differentiation, 1980, 17(1-3):93-103. Kulkarni RM, et al. Evaluation of genetic toxicity of 6-diazo-5-oxo-l-norleucine (DON). Toxicol Mech Methods. 2017 Sep;27(7):518-527.