TargetMol

Isoangustone A

Product Code:
 
TAR-TN4263
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
 

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CodeSizePrice
TAR-TN4263-1mg1mg£752.00
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Further Information

Bioactivity:
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-κB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
CAS:
129280-34-8
Formula:
C25H26O6
Molecular Weight:
422.47
Pathway:
PI3K/Akt/mTOR signaling; Cell Cycle/Checkpoint; Stem Cells; NF-κb; Proteases/Proteasome; Cytoskeletal Signaling; Immunology/Inflammation; MAPK
Purity:
0.98
SMILES:
CC(C)=CCc1cc(cc(O)c1O)-c1coc2cc(O)c(CC=C(C)C)c(O)c2c1=O
Target:
MMP; GSK-3; NF-κB; ROS; Akt; PI3K; CDK; JNK