TargetMol

Rocaglamide

Product Code:
 
TAR-TQ0131
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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TAR-TQ0131-5mg5mg£848.00
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Quantity:
TAR-TQ0131-1mL1 mL * 10 mM (in DMSO)£1,009.00
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Further Information

Bioactivity:
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.
CAS:
84573-16-0
Formula:
C29H31NO7
Molecular Weight:
505.567
Pathway:
NF-κb; Metabolism; Cytoskeletal Signaling; Apoptosis
Purity:
0.9532
SMILES:
COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C
Target:
HSP; NF-κB; PERK

References

Baumann B, et al. Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells. J Biol Chem. 2002 Nov 22;277(47):44791-800. Luan Z, et al. Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation. Mol Med Rep. 2015 Jan;11(1):203-11. Santagata S, et al. Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state. Science. 2013 Jul 19; 341(6143): 1238303.