TargetMol

Cgp 12388

Product Code:
 
TAR-T30811
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T30811-25mg25mgEnquire
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  • Further Information
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Further Information

Bioactivity:
CGP 12388 is a radioactive ligand derived from a β-adrenergic receptor antagonist and is used for cardiac PET imaging due to its high hydrophilicity and affinity for β-adrenergic receptors.
CAS:
108929-47-1
Formula:
C13H17N3O3
Molecular Weight:
263.297
Purity:
0.98
SMILES:
CC(C)NC[C@@H](O)COc1cccc2=NC(=O)N=c12

Documents

References

1. van Waarde A, Maas B, Doze P, Slart RH, Frijlink HW, Vaalburg W, Elsinga PH. Positron emission tomography studies of human airways using an inhaled beta-adrenoceptor antagonist, S-11C-CGP 12388. Chest. 2005 Oct;128(4):3020-7. PubMed PMID: 16236982. 2. Doze P, Elsinga PH, van Waarde A, Pieterman RM, Pruim J, Vaalburg W, Willemsen AT. Quantification of beta-adrenoceptor density in the human heart with (S)-[11C]CGP 12388 and a tracer kinetic model. Eur J Nucl Med Mol Imaging. 2002 Mar;29(3):295-304. PubMed PMID: 12002702. 3. Elsinga PH, van Waarde A, Jaeggi KA, Schreiber G, Heldoorn M, Vaalburg W. Synthesis and evaluation of (S)-4-(3-(2'-[11C]isopropylamino)-2-hydroxypropoxy) -2H-benzimidazol -2-one ((S)-[11C]CGP 12388) and (S)-4-(3-((1'-[18F]-fluoroisopropyl)amino)-2-hydroxypropoxy) -2H- benzimidazol-2-one ((S)-[18F]fluoro-CGP 12388) for visualization of beta-adrenoceptors with positron emission tomography. J Med Chem. 1997 Nov 7;40(23):3829-35. PubMed PMID: 9371248.