TargetMol

Arenobufagin

Product Code:
 
TAR-T5A2455
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T5A2455-1mg1mg£124.00
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TAR-T5A2455-5mg5mg£187.00
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TAR-T5A2455-1mL1 mL * 10 mM (in DMSO)£198.00
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TAR-T5A2455-10mg10mg£294.00
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TAR-T5A2455-25mg25mg£447.00
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TAR-T5A2455-50mg50mg£614.00
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TAR-T5A2455-100mg100mg£828.00
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TAR-T5A2455-500mg500mg£1,581.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells.
CAS:
464-74-4
Formula:
C24H32O6
Molecular Weight:
416.514
Purity:
0.998
SMILES:
[H][C@]12CC[C@]3([H])[C@]([H])([C@H](O)C(=O)[C@]4(C)[C@H](CC[C@]34O)c3ccc(=O)oc3)[C@@]1(C)CC[C@H](O)C2

References

Zhang DM, et al. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. 2013 Jun;34(6):1331-42. Cruz Jdos S, et al. Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes. Eur J Pharmacol. 1993 Aug 3;239(1-3):223-6. Li M, et al. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012 May 1;83(9):1251-60.