TargetMol

Capsazepine

Product Code:
 
TAR-T7177
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T7177-5mg5mg£109.00
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TAR-T7177-10mg10mg£132.00
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TAR-T7177-1mL1 mL * 10 mM (in DMSO)£138.00
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TAR-T7177-25mg25mg£182.00
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TAR-T7177-50mg50mg£258.00
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TAR-T7177-100mg100mg£373.00
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Further Information

Bioactivity:
Capsazepine is an antagonist of TRPV1 receptor ( IC50 : 562 nM). Capsazepine blocks the painful sensation of heat caused by capsaicin (the active ingredient of chilli pepper) which activates the TRPV1 ion channel. It is therefore considered to be a capsaicin antagonist.
CAS:
138977-28-3
Formula:
C19H21ClN2O2S
Molecular Weight:
376.9
Pathway:
Membrane transporter/Ion channel; Apoptosis
Purity:
0.98
SMILES:
Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1
Target:
Apoptosis; TRP/TRPV Channel

References

Yang MH, Jung SH, Sethi G,et al.Pleiotropic Pharmacological Actions of Capsazepine, a Synthetic Analogue of Capsaicin, against Various Cancers and Inflammatory Diseases[J].Molecules. 2019 Mar 12;24(5). pii: E995. Sung B , Prasad S , Ravindran J , et al. Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS?JNK?CHOP-mediated upregulation of death receptors[J]. Free radical biology & medicine, 2012, 53(10). Lu J, Zhou W, Dou F, et al. TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease. EMBO reports. 2021, 22(6): e52013.