TargetMol

Fisetin

Product Code:
 
TAR-T2879
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2879-100mg100mg£103.00
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Quantity:
TAR-T2879-1mL1 mL * 10 mM (in DMSO)£107.00
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  • Further Information
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Further Information

Bioactivity:
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidant, anticancer, neuroprotection effects.
CAS:
528-48-3
Formula:
C15H10O6
Molecular Weight:
286.24
Pathway:
Metabolism; Chromatin/Epigenetic; DNA Damage/DNA Repair; Apoptosis
Purity:
0.9722
SMILES:
c1cc(c(cc1c1c(c(=O)c2c(o1)cc(cc2)O)O)O)O
Target:
TNF; Sirtuin; PPAR

References

1. Kim SC, et al. Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells. Biochem Biophys Res Commun. 2015 Nov 27;467(4):638-44. 2. Ren Q , F Guo, Tao S , et al. Flavonoid fisetin alleviates kidney inflammation and apoptosis via inhibiting Src-mediated NF-?B p65 and MAPK signaling pathways in septic AKI mice[J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, 122:109772. 3. Kim SC, et al. Biochem Biophys Res Commun. 2015 Nov 27;467(4):638-44. 4. Liang Y, Xu Z, Wu X, et al. Inhibition of hyperpolarization-activated cyclic nucleotide-gated channels with natural flavonoid quercetin[J]. Biochemical and Biophysical Research Communications. 2020 5. Zhang H, Zhang H, Wu X, et al. Fisetin alleviates sepsis-induced multiple organ dysfunction in mice via inhibiting p38 MAPK/MK2 signaling[J]. Acta Pharmacologica Sinica. 2020, 41(10): 1348-1356.