Leinco Technologies

Anti-Human ICAM-1 - Purified in vivo GOLD™ Functional Grade

Product Code:
 
LEI-C372
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
15.2
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Flow Cytometry
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Immunoprecipitation (IP)
  • In Vivo Assay
  • Western Blot (WB)
Shipping:
 
2-8°C
Storage:
 
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
 

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CodeSizePrice
LEI-C372-1.0mg1.0 mg£175.00
Quantity:
LEI-C372-5.0mg5.0 mg£380.00
Quantity:
LEI-C372-25mg25 mg£1,014.00
Quantity:
LEI-C372-50mg50 mg£1,556.00
Quantity:
LEI-C372-100mg100 mg£2,159.00
Quantity:
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This product comes from: US.
Typical lead time: 14-21 working days.
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Further Information

Antigen Distribution:
CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Human infant thymocytes and Sezary cells
Long Description:
ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.
NCBI Gene:
3383
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
Inter-Cellular Adhesion Molecule 1

References

1. Eaton, JW. et al. (1998) J Immunol. 161(8):4268-75. Article Link 2. Schaper, W. et al. (2000) Virchows Arch. 436(3):257-70. Article Link 3. Piela-Smith, TH. et al. (2000) J Immunol.165(9):5255-61. Article Link 4. Li, S. et al. (2009) Biochem Biophys Res Commun. 381: 459 5. Wolf, S. et al. (2009) Pharmacol Rep 61: 22 6. Ozcan, U. et al. (2010) Arch Gynecol Obstet. 281(1):71-6.