Leinco Technologies

Recombinant Rat Fractalkine (Chemokine Domain, aa 25-100)

Product Code:
 
LEI-F1038
Product Group:
 
Recombinant Proteins
Host Type:
 
Rat
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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CodeSizePrice
LEI-F1038-25ug25 ug£580.00
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This product comes from: US.
Typical lead time: 14-21 working days.
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  • Further Information
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Further Information

Long Description:
Fractalkine (FKN) is a transmembrane mucin-chemokine hybrid molecule expressed on activated endothelium1 that mediates attachment and firm adhesion of T cells, monocytes and NK cells.2 FKN plays an important proinflammatory role in rheumatoid arthritis (RA) pathogenesis as characterized by induction of synovial angiogenesis, chemotaxis, activation of monocytes and T cells as well as the stimulation of proliferation and synthesis of matrix degrading enzymes (matrix metalloproteinases, MMP) in synovial fibroblasts. Fractalkine thus may represent a novel target molecule for therapeutic intervention in RA.3 FKN is also an essential biomarker for predicting the prognosis of patients with colorectal cancer (CRC).4
NCBI Gene:
89808
Purity:
>97% by SDS Page and analyzed by silver stain.
Target:
Fractalkine

References

1. Patel, DD. et al. (1998) J Exp Med. 188: 1413 2. Hwang, ST. et al. (1999) Eur J Immunol. 29: 2551 3. Muller, GA. et al. (2008) Z Rheumatol. 67: 424 4. Mori, M. et al. (2005) Int J Oncol. 26: 41