Leinco Technologies

Anti-Human HLA-DP (MHC Class II, Clone B7/21) Monomorphic - PE

Product Code:
 
LEI-H252
Product Group:
 
Primary Antibodies
Host Type:
 
Human
Antibody Isotype:
 
Human IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
B7/21
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
2-8°C
Storage:
 
This R-PE conjugate is stable when stored at 2-8°C. Do not freeze.
 

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CodeSizePrice
LEI-H252-50ug50 ug£188.00
Quantity:
LEI-H252-100ug100 ug£262.00
Quantity:
LEI-H252-200ug200 ug£377.00
Quantity:
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This product comes from: US.
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Further Information

Antigen Distribution:
HLA-DP is expressed on antigen-presenting cells, including macrophages, monocytes, DCs, and B cells, and activated T cells.
Concentration:
0.2 mg/ml
Conjugate/Tag/Label:
R-phycoerythrin (PE)
Format:
This R-phycoerythrin (R-PE) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This R-phycoerythrin (R-PE) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Long Description:
This Recombinant HLA-DP antibody, clone B7/21, recognizes the major histocompatibility complex (MHC) class II molecule Human Leukocyte Antigen - DP isotype (HLA-DP). MHC class II is constitutively expressed on human professional antigen-presenting cells (APCs), including macrophages/monocytes, dendritic cells (DCs), and B cells, and is induced on T cells upon activation1. HLA-DP consists of two transmembrane proteins, a 35 kDa α (heavy) chain and 29 kDa β (light) chain2 encoded by the HLA-DPA1 and HLA-DPB1 genes, respectively, located in the HLA complex of chromosome 6. The N-terminal α1 and β1 domains form the antigen-binding groove, which binds 13-25 aa peptides derived from exogenous antigens3. On APCs, MHC class II plays a critical role in the adaptive immune response by presenting phagocytosed antigens to helper CD4 T cells. The T cell receptor (TCR)/CD3 complex of CD4 T cells interacts with peptide-MHC class II, which induces CD4 T cell activation leading to the coordination and regulation of other effector cells. CD4 molecules also bind to MHC class II, which helps augment TCR signaling4. It has also been demonstrated that MHC class II express on activated T cells are capable of antigen presentation5 and can transduce signals into T cells, enhancing T cell proliferation and activity6. High HLA-DP expression is associated with an increased risk of graft-versus-host disease7. Specific alleles of HLA-DP are associated with autoimmune diseases, including rheumatoid arthritis8.
Target:
HLA-DP Monomorphic

References

1. Holling TM, et al. (2004) Hum Immunol. 65(4):282-90. 2. Mitaksov V & Fremont DH. (2006) J Biol Chem. 281(15):10618-25. 3. Wieczorek M, et al. (2017) Front Immunol. 8:292. 4. Artyomov MN, et al. (2010) Proc Natl Acad Sci USA. 107(39):16916-16921. 5. Barnaba V, et al. (1994) Eur J Immunol. 24(1):71-5. 6. Di Rosa F, et al. (1993) Hum Immunol. 38(4):251-60. 7. Petersdorf EW, et al. (2015) N Engl J Med. 373(7):599-609. 8. Raychaudhuri S, et al. (2012) Nat Genet. 44(3):291-6.