Leinco Technologies

Anti-Mouse IL-21R (Clone 4A9) - APC

Product Code:
 
LEI-I-833
Product Group:
 
Primary Antibodies
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
4A9
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
2 - 8°C Wet Ice
Storage:
 
This Allophyc°Cyanin (APC) conjugate is stable when stored at 2-8°C. Do not freeze.
 

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LEI-I-833-50ug50 ug£207.00
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LEI-I-833-100ug100 ug£307.00
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Further Information

Antigen Distribution:
IL-21R is expressed on most B cells as well as some T cells and NK cells.
Concentration:
0.2 mg/ml
Conjugate/Tag/Label:
Allophycocyanin (APC)
Format:
This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
Rat YB2/0 hybridoma transfectant cell line expressing truncated IL-21R
Long Description:
Interleukin-21 receptor (IL-21R) is a single pass type I membrane protein and a member of the type I cytokine receptor family. It is the receptor for Interleukin-21 (IL-21) and upon binding forms a heterodimer with the common gamma subunit (CD132; IL-2RG). IL-21R and IL-21 are important for the proliferation and differentiation of B cells, T cells, and natural killer cells. They function in survival signalling for antiviral CD8+ T cells during chronic infections and induce growth and differentiation of mature B cells in Ig-secreting plasma cells. Additionally, they prevent T cell exhaustion and viral persistence by limiting virus driven Treg cell proliferation1. IL-21 and IL21-R function as early as the pro-B cell stage, with receptor-mediated signalling increasing as cells mature2. When IL-21R binds IL-21, the JAK/STAT transduction pathway is activated. 4A9 was generated by immunizing Lewis rats with IL-21R-transfected YB2/0 and subsequent fusion of immunized spleen cells to SP2/03. FACS analysis and immunoprecipitation studies show that 4A9 selectively binds to IL-21R. Additionally, 4A9 stains the majority of spleen cells from wild type C57BL/6 mice but not IL-21R deficient mice. IL-21 blocks the binding of 4A9 to IL-21R-transfected YB2/0 cells.
NCBI Gene:
60505
Target:
IL-21R

References

1. Schmitz I, Schneider C, Fr?hlich A, et al. PLoS Pathog. 9(5):e1003362. 2013. 2. Simard N, Konforte D, Tran AH, et al. J Immunol. 186(9):5244-5253. 2011. 3. Jin H, Carrio R, Yu A, et al. J Immunol. 173(1):657-665. 2004. 4. DeKoter RP, Geadah M, Khoosal S, et al. J Immunol. 185(12):7374-7384. 2010.