Recombinant Human ApoE4

Product Code:

LEI-A121

Product Group:

Recombinant Proteins

Host Type:

Human

Regulatory Status:

RUO

Shipping:

Ambient

Storage:

This lyophilized protein is stable for twelve months when stored at -20°C to -70°C. After aseptic reconstitution this protein may be stored for one month at 2°C to 8°C or for three months at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Code	Size	Price

LEI-A121-100ug

100 ug

£247.00

Quantity:

LEI-A121-500ug

500 ug

£352.00

Quantity:

Prices exclude any Taxes / VAT

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Further Information

Conjugate/Tag/Label:

Purified No Carrier Protein

Format:

This lyophilized protein is 0.22 um sterile filtered and lyophilized from 20 mM Sodium Phosphate, pH 7.8 + 0.5 mM DTT.

Formulation:

This lyophilized protein is 0.22 um sterile filtered and lyophilized from 20 mM Sodium Phosphate, pH 7.8 + 0.5 mM DTT.

Long Description:

Apolipoprotein E (ApoE) is a 299 amino acid protein, produced by the liver and circulating macrophages, that is a constituent of every plasma lipoprotein except the smallest low density lipoproteins (LDL). It is a key player in the recycling and redistribution of lipids and cholesterol. ApoE is a ligand with a high affinity for low density lipoprotein receptors (LDLR). It regulates the activity of enzymes that metabolize lipids and also make lipids soluble. Mice and humans that lack ApoE cannot remove excess lipoproteins from the plasma and have an increased risk of atherosclerosis. Defective binding of ApoE to its receptors will lead to accumulation of cholesterol-rich lipoprotein particles in the plasma; this is the cause of type III hyperlipoproteinemia. There are three main isoforms of ApoE all products of alleles at a single gene locus: E2 (Cys112, Cys158), E3 (Cys112, Arg158), and E4 (Arg112, Arg158).

NCBI Gene:

348

Purity:

?90% by SDS PAGE