Leinco Technologies

Anti- Pregnancy Associated Plasma Protein A (PAPP-A) (Clone PAPP-2380)

Product Code:
 
LEI-P518
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
PAPP-2380
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunoprecipitation (IP)
Shipping:
 
2 - 8°C Wet Ice
Storage:
 
This purified antibody is stable when stored at 2-8°C. Do not freeze.
 

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LEI-P518-250ug250 ug£434.00
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This product comes from: US.
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  • Further Information
  • References
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Further Information

Concentration:
?1.0 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
Formulated in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
Formulated in 0.01 M phosphate buffered saline, pH 7.2 and contains 0.1% sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Long Description:
Pregnancy-associated plasma protein-A (PAPPA) is a secreted metalloproteinase that cleaves insulin-like growth factor binding proteins to increase the bioavailability of insulin-like growth factors1. Currently, in conjunction with other biomarkers, it is used in prenatal screening for chromosomal abnormalities including Down syndrome2. PAPPA has emerged as a valuable marker in cardiovascular medicine, where elevated levels are associated with an increased risk of adverse cardiovascular events3. It has also been shown to be useful in the detection of gestational diabetes1 and thyroid cancer 4.
Purity:
?90%
Target:
PAPP-A

References

1. Rojas-Rodriguez, R., et. al. Sci Transl Med. 2020. 12(517):eaay4145. 2. Shiefa S, et. al. Indian J Clin Biochem. 2013. 28(1):3-12. 3. Mythili S, Malathi N. Biomed Rep. 2015. 3(6):743-748. 4. Marzocchi C, et. al. Int J Mol Sci. 2022. 23(9):4648.