Elabscience

Recombinant Glucocorticoid Receptor Monoclonal Antibody

Product Code:
 
E-AB-81561
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
R04-8C8
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
1 / 2
Western blot detection of Glucocorticoid Receptor in K562,3T3,Hela cell lysates using Glucocorticoid Receptor Rabbit mAb(1:1000 diluted).Predicted band size:86kDa.Observed band size: 94,91kDa.
2 / 2
Immunofluorescence of Glucocorticoid Receptor(green) in Hela cells using Glucocorticoid Receptor Rabbit mAb at dilution 1:50, and DAPI(blue)
❮❯

Western blot detection of Glucocorticoid Receptor in K562,3T3,Hela cell lysates using Glucocorticoid Receptor Rabbit mAb(1:1000 diluted).Predicted band size:86kDa.Observed band size: 94,91kDa.
Immunofluorescence of Glucocorticoid Receptor(green) in Hela cells using Glucocorticoid Receptor Rabbit mAb at dilution 1:50, and DAPI(blue)

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E-AB-81561-50uL50uL£184.00
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E-AB-81561-100uL100uL£251.00
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Further Information

Abbreviation:
Glucocorticoid Receptor
Background:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546).
Buffer:
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Calculated MW:
86kDa
Concentration:
300 ug/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:1000 IF 1:50-1:100
Immunogen:
Recombinant protein of mouse Glucocorticoid Receptor
ObservedMW:
94/91kDa
Purification method:
Affinity Purified
Target Synonym:
GR;GCR;GRL;GCCR;GCRST
UNIProt ID:
P06537

Documents