Elabscience

NUAK1 Polyclonal Antibody

Product Code:
 
E-AB-67108
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Western blot analysis of extracts of Rat heart using NUAK1 Polyclonal Antibody at dilution of 1:1000.
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Western blot analysis of extracts of Rat heart using NUAK1 Polyclonal Antibody at dilution of 1:1000.

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E-AB-67108-60uL60uL£210.00
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E-AB-67108-120uL120uL£291.00
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E-AB-67108-200uL200uL£431.00
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Further Information

Abbreviation:
NUAK1
Background:
NUAK family SNF1-like kinase 1also known asAMPK-related protein kinase 5(ARK5) is anenzymethat in humans is encoded by theNUAK1gene. Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
23kDa/74kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:200-1:2000
Immunogen:
Recombinant fusion protein of human NUAK1 (NP_055655.1).
ObservedMW:
74kDa
Purification method:
Affinity purification
Target Synonym:
NUAK1;ARK5
UNIProt ID:
O60285

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