Elabscience

DUT Polyclonal Antibody

Product Code:
 
E-AB-67503
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Rat spleen using DUT Polyclonal Antibody at dilution of 1:100 (40x lens).
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Immunofluorescence analysis of U-2 OS cells using DUT Polyclonal Antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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Immunohistochemistry of paraffin-embedded Rat spleen using DUT Polyclonal Antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis of U-2 OS cells using DUT Polyclonal Antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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E-AB-67503-60uL60uL£210.00
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E-AB-67503-120uL120uL£291.00
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E-AB-67503-200uL200uL£431.00
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Further Information

Abbreviation:
DUT
Background:
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Calculated MW:
17kDa/26kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:1000 IHC 1:50-1:200 IF 1:100-1:200
Immunogen:
Recombinant fusion protein of human DUT (NP_001020419.1).
ObservedMW:
24kDa
Purification method:
Affinity purification
Target Synonym:
DUT;dUTPase
UNIProt ID:
P33316

Documents