Elabscience

FITC Anti-Human CD279/PD-1 Antibody[EH12.2H7]

Product Code:
 
E-AB-F1229C
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, κ
Antibody Clone:
 
EH12.2H7
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
Ice packs
Storage:
 
Store at 2-8°C and protected from prolonged exposure to light. Do not freeze.
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MOLT-4 cells treated with 500 ng/ml Ionomycin and 10 ng/ml Phorbol-12-myristate-13-acetate (PMA) for 24 hours are stained with FITC Anti-Human CD279/PD-1 Antibody (filled gray histogram) or FITC Mouse IgG1, κ Isotype Control (empty black histogram).
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MOLT-4 cells treated with 500 ng/ml Ionomycin and 10 ng/ml Phorbol-12-myristate-13-acetate (PMA) for 24 hours are stained with FITC Anti-Human CD279/PD-1 Antibody (filled gray histogram) or FITC Mouse IgG1, κ Isotype Control (empty black histogram).

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CodeSizePrice
E-AB-F1229C-20Tests20Tests£121.00
Quantity:
E-AB-F1229C-100Tests100Tests£193.00
Quantity:
E-AB-F1229C-100Testsx2100Testsx2£253.00
Quantity:
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Further Information

Abbreviation:
CD279/PD-1
Background:
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Concentration:
5 uL/Test
Conjugation:
FITC
GeneID:
5133
Target Synonym:
PDCD1;PD1;Protein PD-1;hPD-1;
UNIProt ID:
Q15116
Usage:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 uL staining volume or per 100 uL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

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