Elabscience

CBFA2T2 Polyclonal Antibody

Product Code:
 
E-AB-52991
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human breast cancer tissue using CBFA2T2 Polyclonal Antibody at dilution of 1:60(?200)
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Immunohistochemistry of paraffin-embedded Human breast cancer tissue using CBFA2T2 Polyclonal Antibody at dilution of 1:60(?200)

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E-AB-52991-20uL20uL£125.00
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E-AB-52991-60uL60uL£172.00
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E-AB-52991-120uL120uL£237.00
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E-AB-52991-200uL200uL£344.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
CBFA2T2
Background:
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Buffer:
PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Concentration:
1.08 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:300, ELISA 1:5000-1:10000
Immunogen:
Fusion protein of human CBFA2T2
Purification method:
Antigen affinity purification
Target Synonym:
AML1 MTG8;cbfa2t2;Core binding factor runt domain alpha subunit 2 translocated to 2;core-binding factor; runt domain; alpha subunit 2;DKFZp313F2116;EHT;ETO homolog on chromosome 20;ETO homologous on chromosome 20;MTG 8 like protein;MTG 8 related protein 1;MTG8 like protein;MTG8 related protein 1;MTG8-like protein;MTG8-related protein 1;MTG8R;MTGR 1;Myeloid translocation gene related protein 1;Myeloid translocation related protein 1;Myeloid translocation-related protein 1;p85;Protein CBFA2T2;ZMYND 3;ZMYND3
UNIProt ID:
O43439

Documents