Elabscience

HMGB1 Polyclonal Antibody

Product Code:
 
E-AB-70044
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry analysis of paraffin-embedded Human liver cancer using HMGB1 Polyclonal Antibody at dilution of 1:500.
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Immunohistochemistry analysis of paraffin-embedded Human Tonsil using HMGB1 Polyclonal Antibody(Elabscience Product Detected by Lifespan).
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Immunohistochemistry analysis of paraffin-embedded Human liver cancer using HMGB1 Polyclonal Antibody at dilution of 1:500.
Immunohistochemistry analysis of paraffin-embedded Human Tonsil using HMGB1 Polyclonal Antibody(Elabscience Product Detected by Lifespan).

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E-AB-70044-60uL60uL£184.00
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E-AB-70044-120uL120uL£251.00
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E-AB-70044-200uL200uL£351.00
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  • Further Information
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Further Information

Abbreviation:
HMGB1
Background:
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NFB family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Calculated MW:
25kDa
Concentration:
1.45 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:200-1:800, IF 1:200-1:800
Immunogen:
KLH conjugated Synthetic peptide corresponding to Mouse HMGB1
ObservedMW:
25kDa
Purification method:
Affinity purification
Target Synonym:
Amphoterin;Chromosomal protein;nonhistone;HMG1;DKFZp686A04236;High mobility group 1;High mobility group box 1;High mobility group protein 1;High mobility group protein B1;high-mobility group (nonhistone chromosomal) protein 1;HMG-1;HMG1;HMG3;HMGB 1;HMGB1;HMGB1;NONHISTONE CHROMOSOMAL PROTEIN HMG1;SBP 1;Sulfoglucuronyl carbohydrate binding protein
UNIProt ID:
P09429,P63158,P63159

Documents

References

  • https://pubs.acs.org/doi/abs/10.1021/acsami.2c09462