Elabscience

CCM2 Polyclonal Antibody

Product Code:
 
E-AB-63185
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Immunohistochemistry (IHC)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Rat heart using CCM2 Polyclonal Antibody at dilution of 1:100 (40x lens).
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Immunohistochemistry of paraffin-embedded Rat heart using CCM2 Polyclonal Antibody at dilution of 1:100 (40x lens).

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E-AB-63185-60uL60uL£210.00
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E-AB-63185-120uL120uL£291.00
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E-AB-63185-200uL200uL£431.00
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Further Information

Abbreviation:
CCM2
Background:
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:50-1:200
Immunogen:
Recombinant fusion protein of human CCM2 (NP_113631.1).
Purification method:
Affinity purification
Target Synonym:
CCM2;C7orf22;OSM;PP10187
UNIProt ID:
Q9BSQ5

Documents