Elabscience

CASP1 Polyclonal Antibody

Product Code:
 
E-AB-70300
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry analysis of paraffin-embedded human tonsil using CASP1 Polyclonal Antibody at dilution of 1:300.
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Immunohistochemistry analysis of paraffin-embedded human tonsil using CASP1 Polyclonal Antibody at dilution of 1:300.

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E-AB-70300-200uL200uL£351.00
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Further Information

Abbreviation:
CASP1
Background:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Buffer:
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Calculated MW:
45kDa
Concentration:
1.2 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:300-1:800
Immunogen:
Recombinant protein corresponding to Mouse Caspase1
ObservedMW:
45-47kDa,30kDa,35kDa
Purification method:
Affinity purification
Target Synonym:
CASP-1;CASP1;CASP1;Caspase 1;Caspase-1 subunit p10;ICE;IL-1 beta-converting enzyme;IL-1BC;IL1 beta converting enzyme;IL1B convertase;Interleukin 1 beta convertase;Interleukin 1B converting enzyme;Interleukin-1 beta convertase;Interleukin-1 beta-converting enzyme;p45
UNIProt ID:
P29466,P29452,P43527

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