Elabscience

GSK3 beta Monoclonal Antibody

Product Code:
 
E-AB-22220
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Mouse
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Clone:2C6
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using GSK3 beta Monoclonal Antibody at dilution of 1:200.
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Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using GSK3 beta Monoclonal Antibody at dilution of 1:200.

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E-AB-22220-20uL20uL£125.00
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E-AB-22220-60uL60uL£172.00
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E-AB-22220-120uL120uL£237.00
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E-AB-22220-200uL200uL£344.00
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This product comes from: China.
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Further Information

Abbreviation:
GSK3 beta
Background:
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-2000, IHC 1:100-200
Immunogen:
Synthetic Peptide of GSK3β
ObservedMW:
46kDa
Purification method:
Protein A purification
Target Synonym:
Glycogen Synthase Kinase 3 Beta;Glycogen synthase kinase-3 beta;GSK 3 beta;GSK-3 beta;GSK3B;GSK3B;GSK3beta isoform;Serine/threonine-protein kinase GSK3B
UNIProt ID:
P49841

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