Elabscience

STAT1 Monoclonal Antibody

Product Code:
 
E-AB-22201
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Mouse
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Clone:8H11
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Immunohistochemistry- Paraffin Embedded (IHC-P)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
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Immunohistochemistry of paraffin-embedded Human colon tissue using STAT1 Monoclonal Antibody at dilution of 1:200.
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Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using STAT1 Monoclonal Antibody at dilution of 1:200.
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Immunohistochemistry of paraffin-embedded Human colon tissue using STAT1 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using STAT1 Monoclonal Antibody at dilution of 1:200.

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E-AB-22201-20uL20uL£125.00
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E-AB-22201-60uL60uL£172.00
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E-AB-22201-120uL120uL£237.00
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E-AB-22201-200uL200uL£344.00
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This product comes from: China.
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Further Information

Abbreviation:
STAT1 Mouse (8H11)
Background:
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Buffer:
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
IHC 1:100-200
Immunogen:
Synthetic Peptide of STAT1
Purification method:
Protein A purification
Target Synonym:
Signal transducer and activator of transcription 1 91kD;CANDF7;DKFZp686B04100;IMD31A;IMD31B;IMD31C;ISGF 3;ISGF-3;OTTHUMP00000163552;OTTHUMP00000165046;OTTHUMP00000165047;OTTHUMP00000205845;Signal transducer and activator of transcription 1 91kDa;Signal transducer and activator of transcription 1;Signal transducer and activator of transcription 1;91kD;Signal transducer and activator of transcription 1-alpha/beta;STAT 1;Stat1;STAT1;STAT91;Transcription factor ISGF 3 components p91 p84;Transcription factor ISGF-3 components p91/p84
UNIProt ID:
P42224

Documents