Elabscience

RAD50 Polyclonal Antibody

Product Code:
 
E-AB-12632
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
-20°C
1 / 3
Western Blot analysis of 293T, Hela, K562, NIH/3T3 and RAW264.7 cell using RAD50 Polyclonal Antibody at dilution of 1:900
2 / 3
Immunohistochemistry of paraffin-embedded Human colon cancer using RAD50 Polyclonal Antibody at dilution of 1:40
3 / 3
Immunohistochemistry of paraffin-embedded Human gastric cancer using RAD50 Polyclonal Antibody at dilution of 1:40
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Western Blot analysis of 293T, Hela, K562, NIH/3T3 and RAW264.7 cell using RAD50 Polyclonal Antibody at dilution of 1:900
Immunohistochemistry of paraffin-embedded Human colon cancer using RAD50 Polyclonal Antibody at dilution of 1:40
Immunohistochemistry of paraffin-embedded Human gastric cancer using RAD50 Polyclonal Antibody at dilution of 1:40

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E-AB-12632-20uL20uL£125.00
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E-AB-12632-60uL60uL£172.00
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E-AB-12632-120uL120uL£237.00
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E-AB-12632-200uL200uL£344.00
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  • Further Information
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Further Information

Abbreviation:
RAD50
Background:
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
Buffer:
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Calculated MW:
154kDa
Concentration:
0.4 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000, IHC 1:50-1:200
Immunogen:
Synthetic peptide of human RAD50
Purification method:
Affinity purification
Target Synonym:
DNA repair protein RAD50;hRAD50;hsRAD50;Mrell;NBSLD;Rad 50;RAD50 2;rad50;RAD50 homolog (S cerevisiae);RAD50 homolog;RAD50 PEN;RAD50;S. cerevisiae;homolog of;RAD50;RAD502;Rad50l;Truncated RAD50 protein
UNIProt ID:
Q92878

Documents

References

  • https://link.springer.com/content/pdf/10.1007/s12035-020-01884-8.pdf